What is an acquired, superficial, thickened patch of epidermis caused by repetitive pressure?

The correct answer is that an acquired, superficial, thickened patch of epidermis caused by repetitive pressure is best described as a callus. A callus forms as a protective response to friction, pressure, or irritation, leading to the thickening of the outer layer of skin (epidermis) in the affected area. Calluses are typically found on the palms of the hands or the soles of the feet, where repeated pressure is common.

Keratoma, while also a thickening of the skin, typically refers to a growth resulting from a keratin buildup due to various irritations or conditions, rather than specifically from repetitive pressure. Corns, on the other hand, are smaller and more localized than calluses and are specifically formed on the toes or bony prominences; they have a core that may be painful when pressed. Warts are caused by viral infections and have a very different etiology, not related to pressure or friction.

In summary, the definition given aligns most closely with how calluses develop, resulting from chronic mechanical irritation, making it the correct choice.