Which factors can lead to the formation of wheals?

Wheals, also known as hives or urticaria, are raised, itchy welts that develop on the skin as a result of a specific inflammatory response. Insect bites are a common trigger for the formation of wheals because they can introduce foreign proteins into the body, prompting an immune response. This leads to the release of histamines and other chemicals that cause blood vessels to leak fluid, resulting in swelling and the characteristic raised appearance of wheals.

While exposure to sunlight, hydration levels, and extreme temperatures can affect the skin's condition, they do not typically trigger wheals in the same way that insect bites do. Insect bites often provoke an immediate local allergic response, which is directly responsible for the development of wheals.